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Influence of S-Adenosylmethionine Pool Size on Spontaneous Mutation, Dam Methylation, and Cell Growth of Escherichia coli

Escherichia coli strains that are deficient in the Ada and Ogt DNA repair methyltransferases display an elevated spontaneous G:C-to-A:T transition mutation rate, and this increase has been attributed to mutagenic O(6)-alkylguanine lesions being formed via the alkylation of DNA by endogenous metaboli...

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Bibliografische gegevens
Hoofdauteurs: Posnick, Lauren M., Samson, Leona D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 1999
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC94141/
https://ncbi.nlm.nih.gov/pubmed/10542178
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