Generation of a strong mutator phenotype in yeast by imbalanced base excision repair

Increased spontaneous mutation is associated with increased cancer risk. Here, by using a model system, we show that spontaneous mutation can be increased several hundred-fold by a simple imbalance between the first two enzymes involved in DNA base excision repair. The Saccharomyces cerevisiae MAG1...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Glassner, Brian J., Rasmussen, Lene Juel, Najarian, Mark T., Posnick, Lauren M., Samson, Leona D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9707589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.17.9997
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