Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
Increased spontaneous mutation is associated with increased cancer risk. Here, by using a model system, we show that spontaneous mutation can be increased several hundred-fold by a simple imbalance between the first two enzymes involved in DNA base excision repair. The Saccharomyces cerevisiae MAG1...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
1998
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21450/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9707589/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.17.9997 |
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