Generation of a strong mutator phenotype in yeast by imbalanced base excision repair

Increased spontaneous mutation is associated with increased cancer risk. Here, by using a model system, we show that spontaneous mutation can be increased several hundred-fold by a simple imbalance between the first two enzymes involved in DNA base excision repair. The Saccharomyces cerevisiae MAG1...

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Main Authors: Glassner, Brian J., Rasmussen, Lene Juel, Najarian, Mark T., Posnick, Lauren M., Samson, Leona D.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC21450/
https://ncbi.nlm.nih.gov/pubmed/9707589
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