Safety, Tolerance, and Pharmacokinetics of High-Dose Liposomal Amphotericin B (AmBisome) in Patients Infected with Aspergillus Species and Other Filamentous Fungi: Maximum Tolerated Dose Study

We conducted a phase I-II study of the safety, tolerance, and plasma pharmacokinetics of liposomal amphotericin B (L-AMB; AmBisome) in order to determine its maximally tolerated dosage (MTD) in patients with infections due to Aspergillus spp. and other filamentous fungi. Dosage cohorts consisted of...

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Publicado en:	Antimicrob Agents Chemother
Principais autores:	Walsh, Thomas J., Goodman, Jesse L., Pappas, Peter, Bekersky, Ihor, Buell, Donald N., Roden, Maureen, Barrett, John, Anaissie, Elias J.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2001
Assuntos:	Pharmacology
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709329/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3487-3496.2001
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