Pharmacokinetic and Pharmacodynamic Modeling of Anidulafungin (LY303366): Reappraisal of Its Efficacy in Neutropenic Animal Models of Opportunistic Mycoses Using Optimal Plasma Sampling

The compartmental pharmacokinetics of anidulafungin (VER-002; formerly LY303366) in plasma were characterized with normal rabbits, and the relationships between drug concentrations and antifungal efficacy were assessed in clinically applicable infection models in persistently neutropenic animals. At...

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Autori principali: Groll, Andreas H., Mickiene, Diana, Petraitiene, Ruta, Petraitis, Vidmantas, Lyman, Caron A., Bacher, John S., Piscitelli, Stephen C., Walsh, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90741/
https://ncbi.nlm.nih.gov/pubmed/11557479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2845-2855.2001
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