Pharmacokinetic and Pharmacodynamic Modeling of Anidulafungin (LY303366): Reappraisal of Its Efficacy in Neutropenic Animal Models of Opportunistic Mycoses Using Optimal Plasma Sampling

The compartmental pharmacokinetics of anidulafungin (VER-002; formerly LY303366) in plasma were characterized with normal rabbits, and the relationships between drug concentrations and antifungal efficacy were assessed in clinically applicable infection models in persistently neutropenic animals. At...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Groll, Andreas H., Mickiene, Diana, Petraitiene, Ruta, Petraitis, Vidmantas, Lyman, Caron A., Bacher, John S., Piscitelli, Stephen C., Walsh, Thomas J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2001
Pynciau:
Experimental Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC90741/
https://ncbi.nlm.nih.gov/pubmed/11557479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2845-2855.2001
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