Correlation between In Vitro and In Vivo Activities of GM 237354, a New Sordarin Derivative, against Candida albicans in an In Vitro Pharmacokinetic-Pharmacodynamic Model and Influence of Protein Binding

The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) which reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis. Immunocompetent mice infe...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Aviles, P., Falcoz, C., Guillén, M. J., San Roman, R., Gómez De Las Heras, F., Gargallo-Viola, D.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2001
Assuntos:	Experimental Therapeutics
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90726/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11557464/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.10.2746-2754.2001
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