Correlation between In Vitro and In Vivo Activities of GM 237354, a New Sordarin Derivative, against Candida albicans in an In Vitro Pharmacokinetic-Pharmacodynamic Model and Influence of Protein Binding

The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) which reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis. Immunocompetent mice infe...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Aviles, P., Falcoz, C., Guillén, M. J., San Roman, R., Gómez De Las Heras, F., Gargallo-Viola, D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2001
Schlagworte:	Experimental Therapeutics
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90726/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11557464/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.10.2746-2754.2001
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!