Correlation between In Vitro and In Vivo Activities of GM 237354, a New Sordarin Derivative, against Candida albicans in an In Vitro Pharmacokinetic-Pharmacodynamic Model and Influence of Protein Binding

The antifungal effect of GM 237354, a sordarin derivative, was studied in an in vitro pharmacokinetic (PK)-pharmacodynamic dynamic system (bioreactor) which reproduces PK profiles observed in a previously described model of drug efficacy against murine systemic candidiasis. Immunocompetent mice infe...

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Detalhes bibliográficos
Main Authors: Aviles, P., Falcoz, C., Guillén, M. J., San Roman, R., Gómez De Las Heras, F., Gargallo-Viola, D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90726/
https://ncbi.nlm.nih.gov/pubmed/11557464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.10.2746-2754.2001
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