Structural Analysis of Chloroquine Resistance Reversal by Imipramine Analogs

For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the di...

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Main Authors: Bhattacharjee, Apurba K., Kyle, Dennis E., Vennerstrom, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC90710/
https://ncbi.nlm.nih.gov/pubmed/11502547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2655-2657.2001
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