Efficacy of Proton Pump Inhibitor Drugs against Plasmodium falciparum In Vitro and Their Probable Pharmacophores

The substituted benzimidazoles omeprazole, lansoprazole, rabeprazole, and pantoprazole were found to have in vitro activity against three different isolates of Plasmodium falciparum: D6 (which is chloroquine and pyrimethamine sensitive), W2 (chloroquine and pyrimethamine resistant), and TM91C235 (mu...

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Detalhes bibliográficos
Main Authors: Riel, Michael A., Kyle, Dennis E., Bhattacharjee, Apurba K., Milhous, Wilbur K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127369/
https://ncbi.nlm.nih.gov/pubmed/12121943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2627-2632.2002
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