Efficacy of Proton Pump Inhibitor Drugs against Plasmodium falciparum In Vitro and Their Probable Pharmacophores

The substituted benzimidazoles omeprazole, lansoprazole, rabeprazole, and pantoprazole were found to have in vitro activity against three different isolates of Plasmodium falciparum: D6 (which is chloroquine and pyrimethamine sensitive), W2 (chloroquine and pyrimethamine resistant), and TM91C235 (mu...

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Autori principali: Riel, Michael A., Kyle, Dennis E., Bhattacharjee, Apurba K., Milhous, Wilbur K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC127369/
https://ncbi.nlm.nih.gov/pubmed/12121943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2627-2632.2002
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