Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative

BG958 reverses resistance in chloroquine-resistant isolates from different countries. Five mutations in the Plasmodium falciparum crt (pfcrt) gene resulting in the amino acid changes K76T, M74I, N75E, A220S, and R371I are systematically identified in resistance-reversed Asian, African, and Brazilian...

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Autori principali: Millet, Julie, Alibert, Sandrine, Torrentino-Madamet, Marylin, Rogier, Christophe, Santelli-Rouvier, Christiane, Bigot, Patricia, Mosnier, Joel, Baret, Eric, Barbe, Jacques, Parzy, Daniel, Pradines, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC529231/
https://ncbi.nlm.nih.gov/pubmed/15561869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4869-4872.2004
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