Activity of LY333328 in Experimental Meningitis Caused by a Streptococcus pneumoniae Strain Susceptible to Penicillin

In a rabbit model of Streptococcus pneumoniae meningitis single doses of 10 and 2.5 mg of the glycopeptide LY333328 per kg of body weight reduced bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as ceftriaxone at 10 mg/kg/h (changes in log CFU, −0.29 ± 0.21 and −0.26 ± 0.22 versus −0....

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Autors principals: Gerber, Joachim, Smirnov, Alexander, Wellmer, Andreas, Ragheb, Jasmin, Prange, Juliane, Schütz, Eckhardt, Wettich, Klaus, Kalich, Siegfried, Nau, Roland
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC90624/
https://ncbi.nlm.nih.gov/pubmed/11408247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.7.2169-2172.2001
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