Activity of LY333328 in Experimental Meningitis Caused by a Streptococcus pneumoniae Strain Susceptible to Penicillin

In a rabbit model of Streptococcus pneumoniae meningitis single doses of 10 and 2.5 mg of the glycopeptide LY333328 per kg of body weight reduced bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as ceftriaxone at 10 mg/kg/h (changes in log CFU, −0.29 ± 0.21 and −0.26 ± 0.22 versus −0....

Disgrifiad llawn

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Antimicrob Agents Chemother
Prif Awduron:	Gerber, Joachim, Smirnov, Alexander, Wellmer, Andreas, Ragheb, Jasmin, Prange, Juliane, Schütz, Eckhardt, Wettich, Klaus, Kalich, Siegfried, Nau, Roland
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology (ASM) 2001
Pynciau:	Experimental Therapeutics
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90624/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11408247/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.7.2169-2172.2001
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!