Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae

A Klebsiella pneumoniae isolate showing moderate to high-level imipenem and meropenem resistance was investigated. The MICs of both drugs were 16 μg/ml. The β-lactamase activity against imipenem and meropenem was inhibited in the presence of clavulanic acid. The strain was also resistant to extended...

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Bibliographic Details
Main Authors: Yigit, Hesna, Queenan, Anne Marie, Anderson, Gregory J., Domenech-Sanchez, Antonio, Biddle, James W., Steward, Christine D., Alberti, Sebastian, Bush, Karen, Tenover, Fred C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90438/
https://ncbi.nlm.nih.gov/pubmed/11257029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.4.1151-1161.2001
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