Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae

A Klebsiella pneumoniae isolate showing moderate to high-level imipenem and meropenem resistance was investigated. The MICs of both drugs were 16 μg/ml. The β-lactamase activity against imipenem and meropenem was inhibited in the presence of clavulanic acid. The strain was also resistant to extended...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Yigit, Hesna, Queenan, Anne Marie, Anderson, Gregory J., Domenech-Sanchez, Antonio, Biddle, James W., Steward, Christine D., Alberti, Sebastian, Bush, Karen, Tenover, Fred C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90438/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11257029/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.4.1151-1161.2001
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