In Vitro Activity of a Novel Antimycobacterial Compound, N-Octanesulfonylacetamide, and Its Effects on Lipid and Mycolic Acid Synthesis

β-Sulfonyl carboxamides have been proposed to serve as transition-state analogues of the β-ketoacyl synthase reaction involved in fatty acid elongation. We tested the efficacy of N-octanesulfonylacetamide (OSA) as an inhibitor of fatty acid and mycolic acid biosynthesis in mycobacteria. Using the BA...

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Hlavní autoři: Parrish, Nikki M., Houston, Todd, Jones, Paul B., Townsend, Craig, Dick, James D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC90437/
https://ncbi.nlm.nih.gov/pubmed/11257028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.4.1143-1150.2001
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