Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits

The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits th...

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Autores principales: Clemons, Karl V., Sobel, Raymond A., Williams, Paul L., Stevens, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC90337/
https://ncbi.nlm.nih.gov/pubmed/11158765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.612-615.2001
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