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Comparative Toxicities and Pharmacokinetics of Intrathecal Lipid (Amphotericin B Colloidal Dispersion) and Conventional Deoxycholate Formulations of Amphotericin B in Rabbits

The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conventionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits th...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Clemons, Karl V., Sobel, Raymond A., Williams, Paul L., Stevens, David A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90337/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158765/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.612-615.2001
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