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Therapeutic Efficacy of Liposome-Encapsulated Gentamicin in Rat Klebsiella pneumoniae Pneumonia in Relation to Impaired Host Defense and Low Bacterial Susceptibility to Gentamicin

Long-circulating liposomes (LCL) may be used as targeted antimicrobial drug carriers as they localize at sites of infection. As a result, LCL-encapsulated gentamicin (LE-GEN) has demonstrated superior antibacterial activity over the free drug in a single-dose study of immunocompetent rats with Klebs...

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Published in:Antimicrob Agents Chemother
Main Authors: Schiffelers, Raymond M., Storm, Gert, ten Kate, Marian T., Bakker-Woudenberg, Irma A. J. M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90314/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158742/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.464-470.2001
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