Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy

Whole-cell assays were implemented to search for efflux pump inhibitors (EPIs) of the three multidrug resistance efflux pumps (MexAB-OprM, MexCD-OprJ, MexEF-OprN) that contribute to fluoroquinolone resistance in clinical isolates of Pseudomonas aeruginosa. Secondary assays were developed to identify...

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Main Authors: Lomovskaya, Olga, Warren, Mark S., Lee, Angela, Galazzo, Jorge, Fronko, Richard, Lee, May, Blais, Johanne, Cho, Deidre, Chamberland, Suzanne, Renau, Tom, Leger, Roger, Hecker, Scott, Watkins, Will, Hoshino, Kazuki, Ishida, Hiroko, Lee, Ving J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC90247/
https://ncbi.nlm.nih.gov/pubmed/11120952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.1.105-116.2001
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