Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance

Antimalarial resistance develops and spreads when spontaneously occurring mutant malaria parasites are selected by concentrations of antimalarial drug which are sufficient to eradicate the more sensitive parasites but not those with the resistance mutation(s). Mefloquine, a slowly eliminated quinoli...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Simpson, Julie A., Watkins, Emmeline R., Price, Ric N., Aarons, Leon, Kyle, Dennis E., White, Nicholas J.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2000
Fag:	Pharmacology
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90214/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11083649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.12.3414-3424.2000
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