Mefloquine Pharmacokinetic-Pharmacodynamic Models: Implications for Dosing and Resistance

Antimalarial resistance develops and spreads when spontaneously occurring mutant malaria parasites are selected by concentrations of antimalarial drug which are sufficient to eradicate the more sensitive parasites but not those with the resistance mutation(s). Mefloquine, a slowly eliminated quinoli...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Simpson, Julie A., Watkins, Emmeline R., Price, Ric N., Aarons, Leon, Kyle, Dennis E., White, Nicholas J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90214/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11083649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.12.3414-3424.2000
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