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Concentration-Dependent Selection of Small Phenotypic Differences in TEM β-Lactamase-Mediated Antibiotic Resistance

In this paper, the first robust experimental evidence of in vitro and in vivo concentration-dependent selection of low-level antibiotic-resistant genetic variants is described. The work is based on the study of an asymmetric competition assay with pairs of isogenic Escherichia coli strains, differin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Negri, Maria-Cristina, Lipsitch, Marc, Blázquez, Jesús, Levin, Bruce R., Baquero, Fernando
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90089/
https://ncbi.nlm.nih.gov/pubmed/10952599
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