Concentration-Dependent Selection of Small Phenotypic Differences in TEM β-Lactamase-Mediated Antibiotic Resistance

In this paper, the first robust experimental evidence of in vitro and in vivo concentration-dependent selection of low-level antibiotic-resistant genetic variants is described. The work is based on the study of an asymmetric competition assay with pairs of isogenic Escherichia coli strains, differin...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Negri, Maria-Cristina, Lipsitch, Marc, Blázquez, Jesús, Levin, Bruce R., Baquero, Fernando
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90089/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10952599/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.9.2485-2491.2000
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