Efficacy of Oral Cochleate-Amphotericin B in a Mouse Model of Systemic Candidiasis

Amphotericin B (AMB) remains the principal therapeutic choice for deep mycoses. However, its application is limited by toxicity and a route of administration requiring slow intravenous injection. An oral formulation of this drug is desirable to treat acute infections and provide prophylactic therapy...

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Autors principals: Santangelo, Rosaria, Paderu, Padmaja, Delmas, Guillaume, Chen, Zi-Wei, Mannino, Raphael, Zarif, Leila, Perlin, David S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC90069/
https://ncbi.nlm.nih.gov/pubmed/10952579
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