Pharmacokinetics-Pharmacodynamics of a Sordarin Derivative (GM 237354) in a Murine Model of Lethal Candidiasis

Sordarins are a new class of antifungal agents which selectively inhibit fungal protein synthesis (FPS) by impairing the function of elongation factor 2. The present study investigates possible correlations between sordarin pharmacokinetic (PK) properties and therapeutic efficacy, based on a murine...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Autores principales:	Aviles, P., Falcoz, C., San Roman, R., Gargallo-Viola, D.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2000
Materias:	Experimental Therapeutics
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10952576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.9.2333-2340.2000
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