Pharmacokinetics-Pharmacodynamics of a Sordarin Derivative (GM 237354) in a Murine Model of Lethal Candidiasis

Sordarins are a new class of antifungal agents which selectively inhibit fungal protein synthesis (FPS) by impairing the function of elongation factor 2. The present study investigates possible correlations between sordarin pharmacokinetic (PK) properties and therapeutic efficacy, based on a murine...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Aviles, P., Falcoz, C., San Roman, R., Gargallo-Viola, D.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10952576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.9.2333-2340.2000
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