Pharmacokinetics-Pharmacodynamics of a Sordarin Derivative (GM 237354) in a Murine Model of Lethal Candidiasis

Sordarins are a new class of antifungal agents which selectively inhibit fungal protein synthesis (FPS) by impairing the function of elongation factor 2. The present study investigates possible correlations between sordarin pharmacokinetic (PK) properties and therapeutic efficacy, based on a murine...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Aviles, P., Falcoz, C., San Roman, R., Gargallo-Viola, D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10952576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.9.2333-2340.2000
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