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In Vitro Resistance Profile of the Human Immunodeficiency Virus Type 1 Protease Inhibitor BMS-232632

BMS-232632 is an azapeptide human immunodeficiency virus (HIV) type 1 (HIV-1) protease inhibitor that displays potent anti-HIV-1 activity (50% effective concentration [EC(50)], 2.6 to 5.3 nM; EC(90), 9 to 15 nM). In vitro passage of HIV-1 RF in the presence of inhibitors showed that BMS-232632 selec...

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Published in:Antimicrob Agents Chemother
Main Authors: Gong, Yi-Fei, Robinson, Brett S., Rose, Ronald E., Deminie, Carol, Spicer, Timothy P., Stock, David, Colonno, Richard J., Lin, Pin-fang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2000
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90064/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10952574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.9.2319-2326.2000
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