Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus: Different Patterns of Quinolone- Induced Inhibition of DNA Synthesis

The effect of quinolones on the inhibition of DNA synthesis in Staphylococcus aureus was examined by using single resistance mutations in parC or gyrA to distinguish action against gyrase or topoisomerase IV, respectively. Norfloxacin preferentially attacked topoisomerase IV and blocked DNA synthesi...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Fournier, Bénédicte, Zhao, Xilin, Lu, Tao, Drlica, Karl, Hooper, David C.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Mechanisms of Action: Physiological Effects
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90029/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898691/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.8.2160-2165.2000
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