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Modulation of Erm Methyltransferase Activity by Peptides Derived from Phage Display

Combinatorial peptide display on phage M13 protein pIII was used to discover peptide sequences that selectively bind to ErmC′ methyltransferase from Bacillus subtilis. One peptide, Ac-LSGVIAT-NH(2), inhibited methylation in vitro with a 50% inhibitory concentration of 20 μM. Interestingly, the set o...

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Bibliografske podrobnosti
Main Authors: Giannattasio, Robert B., Weisblum, Bernard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC89992/
https://ncbi.nlm.nih.gov/pubmed/10858361
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