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Modulation of Erm Methyltransferase Activity by Peptides Derived from Phage Display

Combinatorial peptide display on phage M13 protein pIII was used to discover peptide sequences that selectively bind to ErmC′ methyltransferase from Bacillus subtilis. One peptide, Ac-LSGVIAT-NH(2), inhibited methylation in vitro with a 50% inhibitory concentration of 20 μM. Interestingly, the set o...

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Detalhes bibliográficos
Main Authors: Giannattasio, Robert B., Weisblum, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89992/
https://ncbi.nlm.nih.gov/pubmed/10858361
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