Efficacy of FK463, a (1,3)-β-d-Glucan Synthase Inhibitor, in Disseminated Azole-Resistant Candida albicans Infection in Mice

The efficacy of FK463, a new (1,3)-β-d-glucan synthase inhibitor, against azole-resistant Candida albicans strains has been studied. The MIC of FK463 was lower than those of azoles and amphotericin B against CDR1-expressing C26 and CaMDR-expressing C40 strains. All mice treated with FK463 (1 mg/kg)...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Maesaki, Shigefumi, Hossain, Mohammad Ashraf, Miyazaki, Yoshitsugu, Tomono, Kazunori, Tashiro, Takayoshi, Kohno, Shigeru
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89945/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817741/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1728-1730.2000
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