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Efficacy of FK463, a (1,3)-β-d-Glucan Synthase Inhibitor, in Disseminated Azole-Resistant Candida albicans Infection in Mice

The efficacy of FK463, a new (1,3)-β-d-glucan synthase inhibitor, against azole-resistant Candida albicans strains has been studied. The MIC of FK463 was lower than those of azoles and amphotericin B against CDR1-expressing C26 and CaMDR-expressing C40 strains. All mice treated with FK463 (1 mg/kg)...

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Autori principali: Maesaki, Shigefumi, Hossain, Mohammad Ashraf, Miyazaki, Yoshitsugu, Tomono, Kazunori, Tashiro, Takayoshi, Kohno, Shigeru
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89945/
https://ncbi.nlm.nih.gov/pubmed/10817741
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