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A New SHV-Derived Extended-Spectrum β-Lactamase (SHV-24) That Hydrolyzes Ceftazidime through a Single-Amino-Acid Substitution (D179G) in the Ω-Loop

A new SHV-derived extended-spectrum β-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzym...

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Bibliografiske detaljer
Main Authors: Kurokawa, Hiroshi, Yagi, Tetsuya, Shibata, Naohiro, Shibayama, Keigo, Kamachi, Kazunari, Arakawa, Yoshichika
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89944/
https://ncbi.nlm.nih.gov/pubmed/10817740
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