A New TEM-Derived Extended-Spectrum β-Lactamase (TEM-91) with an R164C Substitution at the Ω-Loop Confers Ceftazidime Resistance

A new plasmid-mediated TEM-derived extended-spectrum β-lactamase, TEM-91, was identified in a ceftazidime-resistant (MIC, >128 μg per ml) Escherichia coli strain isolated in 1996 in Japan. TEM-91 has three amino acid substitutions, R164C, M184T, and E240K, compared with TEM-1 penicillinase. The isoe...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Kurokawa, Hiroshi, Shibata, Naohiro, Doi, Yohei, Shibayama, Keigo, Kamachi, Kazunari, Yagi, Tetsuya, Arakawa, Yoshichika
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC182605/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12937007/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.9.2981-2983.2003
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