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A New TEM-Derived Extended-Spectrum β-Lactamase (TEM-91) with an R164C Substitution at the Ω-Loop Confers Ceftazidime Resistance

A new plasmid-mediated TEM-derived extended-spectrum β-lactamase, TEM-91, was identified in a ceftazidime-resistant (MIC, >128 μg per ml) Escherichia coli strain isolated in 1996 in Japan. TEM-91 has three amino acid substitutions, R164C, M184T, and E240K, compared with TEM-1 penicillinase. The i...

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Bibliografiske detaljer
Main Authors: Kurokawa, Hiroshi, Shibata, Naohiro, Doi, Yohei, Shibayama, Keigo, Kamachi, Kazunari, Yagi, Tetsuya, Arakawa, Yoshichika
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC182605/
https://ncbi.nlm.nih.gov/pubmed/12937007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.9.2981-2983.2003
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