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Disposition of Intravenous Pyrimethamine in Healthy Volunteers

A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability. We wanted to develop a safe, practicable intravenous (i.v.) formulation of pyrimethamine and charac...

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Detalhes bibliográficos
Main Authors: Almond, D. S., Szwandt, I. S. F., Edwards, G., Lee, M. G., Winstanley, P. A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89934/
https://ncbi.nlm.nih.gov/pubmed/10817730
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