Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers

AMD-3100, a bicyclam, is a novel agent that uniquely inhibits the entry of human immunodeficiency virus type 1 (HIV-1) into CD4(+) T cells via selective blockade of the chemokine CXCR-4 receptor. Twelve healthy volunteers were given AMD-3100 as a single 15-min intravenous infusion at 10, 20, 40, or...

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Detaylı Bibliyografya
Asıl Yazarlar: Hendrix, Craig W., Flexner, Charles, MacFarland, Ronald T., Giandomenico, Christen, Fuchs, Edward J., Redpath, Ella, Bridger, Gary, Henson, Geoffrey W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2000
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC89930/
https://ncbi.nlm.nih.gov/pubmed/10817726
Etiketler: Etiketle
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