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Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers

AMD-3100, a bicyclam, is a novel agent that uniquely inhibits the entry of human immunodeficiency virus type 1 (HIV-1) into CD4(+) T cells via selective blockade of the chemokine CXCR-4 receptor. Twelve healthy volunteers were given AMD-3100 as a single 15-min intravenous infusion at 10, 20, 40, or...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Hendrix, Craig W., Flexner, Charles, MacFarland, Ronald T., Giandomenico, Christen, Fuchs, Edward J., Redpath, Ella, Bridger, Gary, Henson, Geoffrey W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89930/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817726/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1667-1673.2000
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