Comparison of Nikkomycin Z with Amphotericin B and Itraconazole for Treatment of Histoplasmosis in a Murine Model

Nikkomycin Z was tested both in vitro and in vivo for efficacy against Histoplasma capsulatum. Twenty clinical isolates were tested for susceptibility to nikkomycin Z in comparison to amphotericin B and itraconazole. The median MIC was 8 μg/ml with a range of 4 to 64 μg/ml for nikkomycin Z, 0.56 μg/...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Goldberg, Janet, Connolly, Patricia, Schnizlein-Bick, Carol, Durkin, Michelle, Kohler, Stephen, Smedema, Melinda, Brizendine, Edward, Hector, Richard, Wheat, Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89923/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817719/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1624-1629.2000
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