Comparison of Nikkomycin Z with Amphotericin B and Itraconazole for Treatment of Histoplasmosis in a Murine Model

Nikkomycin Z was tested both in vitro and in vivo for efficacy against Histoplasma capsulatum. Twenty clinical isolates were tested for susceptibility to nikkomycin Z in comparison to amphotericin B and itraconazole. The median MIC was 8 μg/ml with a range of 4 to 64 μg/ml for nikkomycin Z, 0.56 μg/...

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Bibliographic Details
Main Authors: Goldberg, Janet, Connolly, Patricia, Schnizlein-Bick, Carol, Durkin, Michelle, Kohler, Stephen, Smedema, Melinda, Brizendine, Edward, Hector, Richard, Wheat, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89923/
https://ncbi.nlm.nih.gov/pubmed/10817719
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