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Absolute Bioavailability and Disposition of (−) and (+) 2′-Deoxy- 3′-Oxa-4′-Thiocytidine (dOTC) following Single Intravenous and Oral Doses of Racemic dOTC in Humans

The purpose of this study was to characterize the pharmacokinetics and determine the absolute bioavailability of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC) (BCH-10652), a novel nucleoside analogue reverse transcriptase inhibitor, in humans. dOTC belongs to the 4′-thio heterosubstituted class of compound...

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Bibliografische gegevens
Hoofdauteurs: Smith, Patrick F., Forrest, Alan, Ballow, Charles H., Martin, David E., Proulx, Louise
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89921/
https://ncbi.nlm.nih.gov/pubmed/10817717
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