Dihydropteroate Synthase of Mycobacterium leprae and Dapsone Resistance

Two Mycobacterium leprae genes, folP1 and folP2, encoding putative dihydropteroate synthases (DHPS), were studied for enzymatic activity and for the presence of mutations associated with dapsone resistance. Each gene was cloned and expressed in a folP knockout mutant of Escherichia coli (C600ΔfolP::...

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書誌詳細

出版年:	Antimicrob Agents Chemother
主要な著者:	Williams, Diana L., Spring, Laynette, Harris, Eugene, Roche, Paul, Gillis, Thomas P.
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 2000
主題:	Mechanisms of Resistance
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1530-1537.2000
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