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Dihydropteroate Synthase of Mycobacterium leprae and Dapsone Resistance

Two Mycobacterium leprae genes, folP1 and folP2, encoding putative dihydropteroate synthases (DHPS), were studied for enzymatic activity and for the presence of mutations associated with dapsone resistance. Each gene was cloned and expressed in a folP knockout mutant of Escherichia coli (C600ΔfolP::...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Williams, Diana L., Spring, Laynette, Harris, Eugene, Roche, Paul, Gillis, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2000
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89908/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1530-1537.2000
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