Dihydropteroate Synthase of Mycobacterium leprae and Dapsone Resistance
Two Mycobacterium leprae genes, folP1 and folP2, encoding putative dihydropteroate synthases (DHPS), were studied for enzymatic activity and for the presence of mutations associated with dapsone resistance. Each gene was cloned and expressed in a folP knockout mutant of Escherichia coli (C600ΔfolP::...
Gespeichert in:
| Veröffentlicht in: | Antimicrob Agents Chemother |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology (ASM)
2000
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89908/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817704/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1530-1537.2000 |
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