Identification of the Novobiocin Biosynthetic Gene Cluster of Streptomyces spheroides NCIB 11891

The novobiocin biosynthetic gene cluster from Streptomyces spheroides NCIB 11891 was cloned by using homologous deoxynucleoside diphosphate (dNDP)-glucose 4,6-dehydratase gene fragments as probes. Double-stranded sequencing of 25.6 kb revealed the presence of 23 putative open reading frames (ORFs),...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Steffensky, Marion, Mühlenweg, Agnes, Wang, Zhao-Xin, Li, Shu-Ming, Heide, Lutz
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Chemistry; Biosynthesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89847/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10770754/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.5.1214-1222.2000
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