Selective Interaction of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Nonnucleoside Inhibitor Efavirenz and Its Thio-Substituted Analog with Different Enzyme-Substrate Complexes

Accumulating data have brought the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) into the forefront of antiretroviral therapy. Among the emerging compounds in this class, a particularly attractive one is efavirenz (Sustiva), recently approved for clinical use by the U.S. Food and Drug...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Maga, Giovanni, Ubiali, Daniela, Salvetti, Raul, Pregnolato, Massimo, Spadari, Silvio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10770750/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.5.1186-1194.2000
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