Selective Interaction of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Nonnucleoside Inhibitor Efavirenz and Its Thio-Substituted Analog with Different Enzyme-Substrate Complexes

Accumulating data have brought the nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) into the forefront of antiretroviral therapy. Among the emerging compounds in this class, a particularly attractive one is efavirenz (Sustiva), recently approved for clinical use by the U.S. Food and Drug...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Maga, Giovanni, Ubiali, Daniela, Salvetti, Raul, Pregnolato, Massimo, Spadari, Silvio
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89843/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10770750/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.5.1186-1194.2000
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