Evernimicin Binds Exclusively to the 50S Ribosomal Subunit and Inhibits Translation in Cell-Free Systems Derived from both Gram-Positive and Gram-Negative Bacteria

Evernimicin (SCH 27899) is a new antibiotic with activity against a wide spectrum of gram-positive bacteria and activity against some gram-negative bacteria. Previous metabolic labeling studies indicated that evernimicin specifically inhibited protein synthesis in Staphylococcus aureus. Using a susc...

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Hauptverfasser: McNicholas, Paul M., Najarian, David J., Mann, Paul A., Hesk, David, Hare, Roberta S., Shaw, Karen J., Black, Todd A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89832/
https://ncbi.nlm.nih.gov/pubmed/10770739
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